The MOUSE ANTI NITROTYROSINE Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, Rat, Amoeba/Protozoa, Bacteria/Archaea, Bovine, C. elegans/Worm, Canine, Chicken/Bird, Donkey, Drosophila/Arthropod, Feline, Goat, Guinea Pig, Hamster, Horse, Mollusc, Non-Human Primate, Plant, Porcine, Reptile, Rabbit, Sheep, Virus, Xenopus/Amphibian, Yeast/Fungi, Zebrafish/Fish, Other Invertebrate, and Other Mammalian antigen. The MOUSE ANTI NITROTYROSINE Antibody has been validated for the following applications: ELISA, Immunoprecipitation, and Western Blot.
Description
Mouse anti Nitrotyrosine antibody, clone 6B2-3G2 recognizes both free and protein-bound nitrotyrosine (Tyr-NO2), including human serum nitro albumin, nitro insulin and nitro haemoglobin. Nitrotyrosine arises from the nitration of protein tyrosine residues, by reactive nitrogen species such as peroxynitrite and nitrogen dioxide, and can be used as a measure of NO-dependent oxidative stress and cell damage. Increased levels of nitrotyrosine are detectable in various pathological conditions including atherosclerosis, rheumatoid arthritis, cardiovascular disease, inflammatory bowel disease and cystic fibrosis (Halliwell 1997). The specificity of Mouse anti Nitrotyrosine antibody, clone 6B2-3G2 as determined by competition ELISA is: Nitrotyrosine:95 % of inhibitionTyrosine:0 % of inhibitionNitrotryptophan:4 % of inhibitionAminotyrosine:0 % of inhibitionPhosphotyrosine:2 % of inhibitionChlorotyrosine:3 % of inhibition